Swindon Town will open their 2020/21 campaign by hosting Rochdale at the County Ground.
| Date | Opponent | H/A |
| Sat. 12/09/20 | Rochdale | Home |
| Sat. 19/09/20 | Blackpool | Away |
| Sat. 26/09/20 | Burton Albion | Home |
| Sat. 03/10/20 | Peterborough United | Away |
| Sat. 10/10/20 | AFC Wimbledon | Home |
| Sat. 17/10/20 | Sunderland | Home |
| Tue. 20/10/20 | Northampton Town | Away |
| Sat. 24/10/20 | Oxford United | Away |
| Tue. 27/10/20 | Accrington Stanley | Home |
| Sat. 31/10/20 | Hull City | Home |
| Tue. 03/11/20 | Plymouth Argyle | Away |
| Sat. 14/11/20 | Shrewsbury Town | Away |
| Sat. 21/11/20 | Bristol Rovers | Home |
| Tue. 24/11/20 | Lincoln City | Home |
| Tue. 01/12/20 | Crewe Alexandra | Away |
| Sat. 05/12/20 | Gillingham | Away |
| Sat. 12/12/20 | Fleetwood Town | Home |
| Tue. 15/12/20 | Doncaster Rovers | away |
| Sat. 19/12/20 | Charlton Athletic | Home |
| Sat. 26/12/20 | Portsmouth | Away |
| Tue. 29/12/20 | Milton Keynes Dons | Home |
| Sat. 02/01/21 | Wigan Athletic | Home |
| Sat. 09/01/21 | Ipswich Town | Away |
| Sat. 16/01/21 | Doncaster Rovers | Home |
| Sat. 23/01/21 | Charlton Athletic | Away |
| Tue. 26/01/21 | Plymouth Argyle | Home |
| Sat. 30/01/21 | Hull City | Away |
| Sat. 06/02/21 | Shrewsbury Town | Home |
| Sat. 13/02/21 | Bristol Rovers | Away |
| Sat. 20/02/21 | Crewe Alexandra | Home |
| Tue. 23/02/21 | Lincoln City | Away |
| Sat. 27/02/21 | Northampton Town | Home |
| Tue. 02/03/21 | Sunderland | Away |
| Sat. 06/03/21 | Accrington Stanley | Away |
| Tue. 09/03/21 | Oxford United | Home |
| Sat. 13/03/21 | Gillingham | Home |
| Sat. 20/03/21 | Fleetwood Town | Away |
| Sat. 27/03/21 | Rochdale | Away |
| Fri. 02/04/21 | Blackpool | Home |
| Mon. 05/04/21 | Burton Albion | Away |
| Sat. 10/04/21 | Peterborough United | Home |
| Sat. 17/04/21 | AFC Wimbledon | Away |
| Tue. 20/04/21 | Portsmouth | Home |
| Sat. 24/04/21 | Milton Keynes Dons | Away |
| Sat. 01/05/21 | Ipswich Town | Home |
| Sat. 08/05/21 | Wigan Athletic | Away |
